What is MOTS-c and how does it function in cellular research?

MOTS-c is a mitochondrial-derived peptide that regulates glucose metabolism and energy homeostasis. It functions as a metabolic regulator by activating the AMPK pathway, mimicking the effects of exercise.

What is the difference between MOTS-c and SS-31?

MOTS-c acts as a systemic metabolic signaling regulator, whereas SS-31 focuses on stabilizing mitochondrial membranes and reducing oxidative stress at the cellular level.

What are the primary applications for MOTS-c?

MOTS-c is used to study metabolic disorders, obesity, insulin resistance and longevity, specifically focusing on its ability to enhance fatty acid oxidation and glucose uptake.

Are your MOTS-c peptides lab-tested for purity?

Yes, all MOTS-c batches are tested via HPLC and Mass Spectrometry to ensure a purity standard of 99% or higher for consistent research outcomes.

How should MOTS-c be stored?

Lyophilized powder should be stored at -20°C. Once reconstituted, it must be kept refrigerated at 2°C to 8°C and utilized within 21 days.

How does MOTS-c mimic exercise?

It activates the AMPK pathway, typically triggered by physical exertion. MOTS-c signals the body to burn fat and take up glucose into muscles chemically, simulating a workout state.

Can MOTS-c help with weight loss without exercise?

Research shows MOTS-c can prevent obesity and reduce visceral fat even on a high-fat diet without exercise, but it is most effective when amplifying an active lifestyle.

Is it better to inject subcutaneously or intramuscularly?

While some prefer intramuscular, subcutaneous administration is the most common and accepted method for metabolic studies due to consistent absorption.

Does it interact with other mitochondrial peptides?

Yes, it is often stacked with SS-31. MOTS-c focuses on metabolic regulation, while SS-31 focuses on repairing mitochondrial damage, offering a complementary effect.

Buy MOTS-c Peptide Online | Mitochondrial Exercise Mimetic

Mots-C

MOTS-c stands out as a revolutionary compound that is fundamentally shifting how scientists understand energy production and weight management. Unlike traditional hormones that act on surface receptors, MOTS-c originates directly from the mitochondrial DNA, the powerhouse of the cell. It acts as a potent signaling molecule that mimics the physiological effects of aerobic exercise, even in the absence of physical activity. This has earned it the nickname exercise in a bottle within the scientific community. For researchers investigating metabolic flexibility, insulin resistance and cellular longevity, the integrity of the peptide is paramount.

Buy MOTS-c Online: The Importance of Purity

When you seek to buy MOTS-c online, you are looking for more than just a chemical; you are looking for biological activity. Mitochondrial peptides are complex and fragile sequences. If not synthesized and lyophilized correctly, the peptide structure can collapse, rendering it useless for research. Many generic suppliers fail to provide the necessary stability for such advanced compounds.

At Peptidesline, we utilize advanced purification processes to ensure that our MOTS-c maintains its bioactivity from our lab to your doorstep. We guarantee high purity, verified by HPLC testing, to ensure that your research data is not compromised by contaminants. Whether you are conducting studies on obesity or endurance, sourcing from a vendor that understands peptide stability is crucial. For those interested in comprehensive metabolic research, you might also explore our weight management peptides section.

What is MOTS-c?

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a peptide of 16 amino acids. It is distinct from most other peptides because it is encoded in the mitochondria rather than the cell’s nucleus. It was discovered fairly recently, in 2015, by researchers at the University of Southern California.

Its primary role is to regulate metabolic homeostasis. It functions as a hormone, traveling from the mitochondria to the nucleus to regulate gene expression in response to metabolic stress. In simple terms, it tells the body to process glucose and fatty acids more efficiently, simulating the cellular state of an athlete. It targets the folate cycle and the skeletal muscle, promoting glucose uptake without increasing insulin, which is a unique and highly sought-after mechanism.

Key Benefits and Mechanism of Action

The potential applications of MOTS-c in research are vast, primarily focusing on metabolic syndrome and physical performance.

Exercise Mimetic Effects: It activates the AMPK pathway, similar to how the body responds to vigorous exercise. This leads to improved endurance and physical capacity in research subjects.
Prevents Diet-Induced Obesity: Studies have shown that MOTS-c administration can prevent weight gain even in the presence of a high-fat diet, suggesting it increases metabolic flexibility.
Insulin Sensitivity: It drastically improves the body’s ability to handle glucose, making it a prime candidate for research into Type 2 diabetes and insulin resistance.
Mitochondrial Biogenesis: It encourages the creation of new mitochondria, effectively upgrading the cell’s energy capacity and potentially slowing down cellular aging.

Researchers often pair MOTS-c with other mitochondrial agents like SS-31 to create a complete protocol for cellular rejuvenation and energy restoration.

Comparison: MOTS-c vs. AICAR

Both MOTS-c and AICAR are famous in the research community as exercise mimetics, but they achieve their results through different pathways. Understanding these differences is vital for selecting the right compound for your study.

Feature	MOTS-c	AICAR
Origin	Mitochondrial DNA (Natural Peptide)	Synthetic Analog of Adenosine
Primary Mechanism	Regulates Folate Cycle & Nuclear Genes	Direct Activation of AMPK Pathway
Effect on Insulin	Highly improves insulin sensitivity	Moderate improvement
Fat Loss Potential	High (Prevents fat storage)	High (Increases fatty acid oxidation)
Best Research Use	Metabolic health, Anti-aging, Weight control	Pure endurance, Stamina enhancement
Cost Factor	Generally more affordable	Typically very expensive

Side Effects and Safety Profile

Because MOTS-c is a peptide naturally found in the human body, the risk of allergic reaction or rejection is significantly lower compared to synthetic drugs. However, owing to its potent effect on metabolism, there are safety considerations to keep in mind during research.

The most common side effect reported is irritation or redness at the injection site, which is standard for most subcutaneous peptides. More importantly, because MOTS-c increases glucose uptake in muscles, there is a theoretical risk of hypoglycemia (low blood sugar) if administered to a subject who has fasted for too long or is on other glucose-lowering medications. Researchers typically monitor glucose levels closely. Additionally, some subjects may experience a temporary increase in body temperature (thermogenesis) as metabolic rate climbs.

Mots-C

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Mots-c

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Buy MOTS-c Online: The Importance of Purity

What is MOTS-c?

Key Benefits and Mechanism of Action

Comparison: MOTS-c vs. AICAR

Side Effects and Safety Profile